Appearing one year after Rhino's Ramones box set Weird Tales of the Ramones, and appearing four years after Rhino's first single-disc Ramones collection Loud, Fast Ramones: Their Toughest Hits – which itself appeared after Rhino's excellent double-disc Hey! Ho! Let's Go!: The Anthology – Rhino's 2006 collection Greatest Hits serves up 20 of the group's basics. Unlike 2002's Loud, Fast Ramones, Greatest Hits makes no attempt to cover anything other than the group's peak period: the first 16 songs cover 1976's Ramones through 1980s End of the Century, with a selection apiece from Pleasant Dreams ("The KKK Took My Baby Away"), Subterranean Jungle ("Outsider"), Brain Drain ("Pet Sematary") and Too Tough to Die ("Wart Hog").

In a way, the Ramones are an ideal band to anthologize. No matter how cohesive their records were (or not), their albums always played like collections of singles and since singles are easy to anthologize, it stands to reason that the best of the Ramones' songs will sound good in nearly any context; hell, the haphazard Ramones Mania proved that. However, Rhino's double-disc Hey! Ho! Let's Go: Ramones Anthology has much greater goals than being just another collection – it strives to be the final word on the Ramones.

The brilliance of this collection is that it combines the standard Brit-punk anthems by the Sex Pistols, the Damned, the Buzzcocks, and Stiff Little Fingers with other great songs that typify the variety and range of punk-era independent music from both sides of the Atlantic. The songs are so well chosen that the punk aesthetic is further revealed by the inclusion of songs that characterize pub rock, new wave, and other related genres. The usual punk suspects ("New Rose," "Anarchy in the UK") are all here, along with many other treasures: Dr. Feelgood's "Milk and Alcohol", Devo's "Mongoloid," Jonathan Richman's "Roadrunner," Talking Heads' "Psycho Killer," and Television's "Marquee Moon." The less commonly anthologized punk selections are inspired, too: the Ruts' "Babylon Is Burning," Generation X's "Ready Steady Go," and X-Ray Spex's "Identity," along with the seminal "Sheena is a Punk Rocker." The conception of the genre is expanded further to include Elvis Costello, Iggy Pop, XTC, Joe Jackson, the Pretenders, the Tubes, and Blondie, and their presence overcomes the tendency for boring repetition on a very long collection.