Signalling Pathways in Acute Oxygen Sensing (Novartis Foundation Symposia) (repost)
Signalling Pathways in Acute Oxygen Sensing (Novartis Foundation Symposia)
Wiley | 2006-03-10 | ISBN: 0470014571 | 300 pages | PDF | 3 MB
Wiley | 2006-03-10 | ISBN: 0470014571 | 300 pages | PDF | 3 MB
Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mechanisms. Some favour the view that the primary signalling event is a reduction in cell redox state and reactive oxygen species (ROS) due to general inhibition of the electron transport chain (ETC); others support a key role for complex III of the ETC and an increase in ROS generation, while others doubt either of these components is the key intermediary.