A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery by Robert A. Goodnow Jr.
English | 2014 | ISBN: 1118487680 | 480 pages | PDF | 6,7 MB
English | 2014 | ISBN: 1118487680 | 480 pages | PDF | 6,7 MB
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening.
The book:
• Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
• Helps chemists generate and screen novel chemical libraries of large size and quality
• Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
• Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery
• Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods