The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic (repost)
The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic
Springer | 2009 | ISBN: 3211782060 | 260 pages | PDF | 6,5 MB
Springer | 2009 | ISBN: 3211782060 | 260 pages | PDF | 6,5 MB
Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance.