Free-Radical Synthesis and Functionalization of Heterocycles (Topics in Heterocyclic Chemistry)
Free-Radical Synthesis and Functionalization of Heterocycles (Topics in Heterocyclic Chemistry) by Yannick Landais
English | 24 Jun. 2018 | ISBN: 3319895206 | 362 Pages | PDF | 9.22 MB
English | 24 Jun. 2018 | ISBN: 3319895206 | 362 Pages | PDF | 9.22 MB
This volume describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural heterocycles. As organic chemists strive towards sustainability, radical chemistry has recently seen major advances and efforts in this direction, including C-H activation of arenes and unactivated alkyl groups. Photochemical activation, for a long time the preferred mode of activation in radical chemistry has also seen an unexpected revival with the advent of visible light metal- and organocatalyzed photoredox processes. A survey of these emerging areas is provided along with the concepts at the origin of these developments.