Immune Dysfunction and Immunotherapy in Heart Disease

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.The four parts of the book address:Immune Dysfunction Leading to Heart Disease: Induction by Physiological ChangesImmune Dysfunction Promoting CVD: Induction by Transplantation DrugsImmune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic DrugsImmune Dysfunction Leading to Heart Disease: Induction by Pathogens Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics. Content: Chapter 1 Immunosuppression by Ultraviolet Light?B Radiation: A Mediator of Cardiac Remodeling (pages 3–5): Sherma Zibadi, Douglas F. Larson and Ronald Ross WatsonChapter 2 Immune Mechanisms in Pediatric Cardiovascular Disease (pages 6–16): Wendy A. Luce, Mandar S. Joshi, Timothy M. Hoffman, Timothy F. Feltes and John Anthony BauerChapter 3 Heart Failure—Role of Autoimmunity (pages 17–27): Urs ErikssonChapter 4 Immune Basis of Hypertension in Humans (pages 28–33): Katherine Horak and Douglas F. LarsonChapter 5 Immune Dysregulation: Potential Mediator of Metabolic Syndrome—Induced Cardiac Remodeling (pages 34–38): Sherma Zibadi, Douglas F. Larson and Ronald Ross WatsonChapter 6 T Helper 2 Cell Cytokines in Remodeling of Aortic Wall (pages 39–47): W. L. ChanChapter 7 Effects of TNF?? on Cardiac Function (pages 48–56): Bo Yang and Douglas F. LarsonChapter 8 Immunosuppression in Promotion of Cardiac Allograft Vasculopathy (pages 57–79): Farzad Moien?Afshari, Jonathan Choy, Bruce M. McManus and Ismail LaherChapter 9 Immunotherapy for Left Ventricular Dysfunction After Heart Transplantation (pages 80–94): Charles E. CanterChapter 10 Immunomodulating Therapy in Chronic Heart Failure (pages 97–108): Lars Gullestad, Jan Kristian Damas, Arne Yndestad and Pal AukrustChapter 11 Statins in Atherosclerosis: Role of Immune Regulation (pages 109–115): Claire Arnaud and Francois MachChapter 12 ACE Inhibitors as Immunomodulators: Treatment of Cardiovascular Disease (pages 116–127): Christina Grothusen and Bernhard SchiefferChapter 13 Treatment of Heart Failure by Anticytokine Therapies (pages 128–132): Donna L. Vredevoe and Julia R. GageChapter 14 Pathogenesis of Cardiovascular Complications in the Acquired Immunodeficiency Syndrome (pages 135–151): Giuseppe BarbaroChapter 15 Cytokines and T Cell?Mediated Responses in Autoimmune Myocarditis (pages 152–156): Jin ZhangChapter 16 Drugs of Abuse: Accentuation of Immunomodulation of Viral Myocarditis (pages 157–171): Oana Madalina Petrescu and James P. MorganChapter 17 Osteopontin: The Link Between the Immune System and Cardiac Remodeling (pages 175–181): Samira Najmaii, Qianli Yu and Douglas F. LarsonChapter 18 Inflammatory Immune Activation in Heart Failure Patients: Therapeutic Implications (pages 182–185): Mohammad Abraham Kazemizadeh Gol and Mohsen Araghi?NiknamChapter 19 Role of Innate Immune Dysregulation in Diabetic Heart Failure (pages 186–194): Betsy B. Dokken and Paul F. McDonaghChapter 20 Tolerance in Heart Transplantation: Current and Future Role (pages 195–206): Kimberly Gandy, Jos Domen and Jack CopelandChapter 21 Neutralization of Th2 Cytokines in Therapy of Cardiovascular Pathology (pages 207–216): A. Mandel and A. E. BoltonChapter 22 Anti?Inflammatory Immune Therapy in Heart Disease (pages 217–226): David Chen, Christian Assad?Kottner, Francisco J. Cordova, Carlos Orrego and Guillermo Torre?AmioneChapter 23 Cholesterol, Interleukin?6 Inflammation, and Atherosclerosis—Role of Statins, Bisphosphonates, and Plant Polyphenols in Atherosclerosis and Other Diseases of Aging (pages 227–255): Sota OmoiguiChapter 24 Autoimmune Myocarditis: Treatment with Anti?T?Cell Antibodies (pages 256–262): Zofia T. Bilinska and Witold RuzylloChapter 25 Immunosuppressive Therapy to Counter Cardiac Allograft Vasculopathy (pages 263–270): Carl V. LeierChapter 26 Role of Oral Pathogens in the Pathogenesis of Coronary Heart Disease (pages 271–279): Palle HolmstrupChapter 27 Myocardial Regenerative Potential by Stem Cell Transplant (pages 280–287): Yinhong Chen, Catherine A. Priest and Joseph D. GoldChapter 28 Bioflavanoids and Dietary Anti?Inflammatory Actions: Role in Cardiovascular Diseases (pages 288–300): Simin Bolourchi?Vaghefi and Amy Galena