MACPF/CDC Proteins - Agents of Defence, Attack and Invasion (Subcellular Biochemistry)
MACPF/CDC Proteins - Agents of Defence, Attack and Invasion (Subcellular Biochemistry) by Gregor Anderluh
English | 19 May 2014 | ISBN: 9401788804 | 344 Pages | EPUB | 4.16 MB
English | 19 May 2014 | ISBN: 9401788804 | 344 Pages | EPUB | 4.16 MB
This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.