"Endothelial Dysfunction: Old Concepts and New Challenges" ed. by Helena Lenasi

The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function.


Contents
1.Endothelium at a Glance
2.Hox Genes in Adult Tissues and Their Role in Endothelial Cell Differentiation and Angiogenesis
3.Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction
4.Targeting Endothelial SIRT1 for the Prevention of Arterial Aging
5.Sensing Fluid-Shear Stress in the Endothelial System with a Special Emphasis on the Primary Cilium
6.Endothelial Dysfunction as a Consequence of Endothelial Glycocalyx Damage: A Role in the Pathogenesis of Preeclampsia
7.Endothelial Cell von Willebrand Factor Secretion in Health and Cardiovascular Disease
8.Hyperglycemia-Induced Endothelial Dysfunction
9.Impact of Advanced Glycation End Products on Endothelial Function and Their Potential Link to Atherosclerosis
10.Endothelial Dysfunction in Type 2 Diabetes: Targeting Inflammation
11.Angiogenesis in Adipose Tissue: How can Moderate Caloric Restriction Affects Obesity-Related Endothelial Dysfunction?
12.Pulmonary Vascular Endothelial Cells
13.Smoking, Respiratory Diseases and Endothelial Dysfunction
14.Vascular Sympathetic Neurotransmission and Endothelial Dysfunction
15.Endothelial Cell Dysfunction in HIV-1 Infection
16.Selected Endothelial Responses after Ionizing Radiation Exposure
17.The Markers of Endothelial Activation




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