"Gene Expression and Regulation in Mammalian Cells: Transcription From General Aspects" ed. by Fumiaki Uchiumi

This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases.

"Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms.

This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.


Contents
1 Introductory Chapter: Current Studies in Transcriptional Control System; Toward the Establishment of Therapies against Human Diseases
2 Regulation of Mammalian Gene Expression
3 Mammalian Cis-Acting RNA Sequence Elements
4 Influence of Endogenous Viral Sequences on Gene Expression
5 Cross-Talk Categorisations in Data-Driven Models of Signalling Networks: A System-Level View
6 Interplay between Transcription and RNA Degradation
7 Post-Transcriptional Control of RNA Expression in Cancer
8 Current Status for Application of RNA Interference Technology as Nucleic Acid Drug
9 Gene Expression during the Activation of Human B Cells
10 The Interplay between Transcription Factors and Epigenetic Modifications in Th2 Cells
11 Post-Transcriptional and Translational Mechanisms of Regulation of Gene Expression in T Cell Subsets
12 Phosphorylation of PRH/HHEX by Protein Kinase CK2 Regulates Cell Proliferation and Cell Migration in Diverse Cell Types
13 Dual Role of METCAM/MUC18 Expression in the Progression of Cancer Cells
14 Methylation of NPkB and its Role in Gene Regulation
15 SOX Genes and Cancer