"Genes and Autoimmunity: Intracellular Signaling and Microbiome Contribution" ed. by Spaska Angelova Stanilova

This book focuses on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity.

Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency.

Contents
Preface
Section 1 Genes and Intracellular Signaling
1 Genetic Susceptibility to Graves' Ophthalmopathy
2 Gene Polymorphisms of Immunoregulatory Cytokines IL-10 and TGF-pl in Systemic Lupus Erythematosus
3 Toll-Like Receptor 3 and Retinoic Acid-Inducible Gene-I Implicated to the Pathogenesis of Autoimmune Renal Diseases
4 Gene Expression Pattern Characterises Development of Multiple Sclerosis
5 Costimulatory Molecules in Rheumatic Diseases Revisited with an Emphasis on Their Roles in Autoimmune Sjogren's Syndrome
6 Immune Synapses Between Lymphocytes and Target Cells in Autoimmune Thyroid Diseases
Section 2 Infectious Agents and Host Inflammatory Response
7 Microbio me and Auto immunity
8 Environmental Factors and Type 1 Diabetes Mellitus in Pediatric Age Group
9 Common Mechanisms of Pathogenesis of Tissue-Specific Autoimmune Diseases: The Edited Model to Illustrate Those for IDDM and Multiple Sclerosis
10 Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Parallels with Autoimmune Disorders
11 Bio markers of Inflammatory Arthritis and Proteomics