Gut and Metabolic Syndrome
Gut and Metabolic Syndrome by Enrico Biffi
Italian | 2016 | ISBN: n/a | 99 pages | PDF | 2.8 MB
Italian | 2016 | ISBN: n/a | 99 pages | PDF | 2.8 MB
Cardiovascular disease (CVD) and other disorders included in the metabolic syndrome (MS) show
common pathogenetic factors including a status of chronic low-grade inflammation (CLGI). Recent insights
have generated an interesting new perspective introducing the possibility that our microbiota might be
involved in the development of these disorders causing a chronic low grade inflammatory status and
metabolic handling of the host. The relationship between microbiota and host is very complex and based on
a mutual influence. Several findings have shown that a number of environmental associated factors, damaging the
permeability of the intestinal barrier, can facilitate the constant transition of small amounts of bacterial
endotoxins in the circulation able to activate, in different organs and tissues, the innate immunity receptors
(PRRs), leading the appearance of a low-grade systemic inflammation.