"Novel Aspects on Motor Neuron Disease" ed. by Humberto Foyaca Sibat, Lourdes de Fátima Ibañez-Valdés

This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities.

Dedicated to our readers, we include novel information about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter.


Contents
1.Introductory Chapter: Introduction to Novel Aspects on Motor Neuron Disease
2.Contribution of Aberrant Astrocytes to Motor Neuron Damage and Death in the SOD1G93A Rat Experimental Model of ALS
3.Stem Cell Therapy in Motor Neuron Disease
4.Introduction to Novel Motor Neuron Disease
5.Novel Aspects on Motor Neuron Disease: The Recent Genetic Studies on ALS
6.Structural and Functional Consequences of the SMA-Linked Missense Mutations of the Survival Motor Neuron Protein: A Brief Update