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"Proteoforms: Concept and Applications in Medical Sciences" ed. by Xianquan Zhan

Posted By: exLib
"Proteoforms: Concept and Applications in Medical Sciences" ed. by Xianquan Zhan

"Proteoforms: Concept and Applications in Medical Sciences" ed. by Xianquan Zhan
ITExLi | 2020 | ISBN: 1838800344 9781838800345 1838800336 9781838800338 1839628324 9781839628320 | 77 pages | PDF | 7 MB

This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.

A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease.

Contents
1.Introductory Chapter: Proteoforms
2.Proteoforms: General Concepts and Methodological Process for Identification
3.Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry
4.Prolactin Proteoform Pattern Changed in Human Pituitary Adenoma Relative to Control Pituitary Tissues
5.Proteoforms in Acute Leukemia: Evaluation of Age- and Disease-Specific Proteoform Patterns

1st true PDF with TOC BookMarkLinks