"Telomere: A Complex End of a Chromosome" ed. by Marcelo L. Larramendy

This book contains the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology.

We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

Contents
Preface
1 Telomeres in Liver Transplantation Allografts
2 Telomere and Telomerase in Cancer
3 Telomeres and Genomic Instability from Precancerous Lesions to Advanced Cancer – Understanding Through Ovarian Cancer
4 The Role of Telomeres and Telomere-associated Proteins as Components of Interactome in Cell-signaling Pathways
5 Molecular Diagnosis and Precision Therapeutic Approaches for Telomere Biology Disorders
6 Telomere Instability Induced by Anticancer Drugs in Mammalian Cells
7 Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases
8 Telomere Length and Its Relation to Human Health
9 On the Far Side of Telomeres: The Many Roles of Telomerase in the Acquisition and Retention of Cancer Stemness