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Plasmacytoid Dendritic Cells

Posted By: AvaxGenius
Plasmacytoid Dendritic Cells

Plasmacytoid Dendritic Cells by Dipyaman Ganguly
English | PDF,EPUB | 2022 | 170 Pages | ISBN : 9811955948 | 25.4 MB

This book provides a systemic review of the development, function, and role of plasmacytoid Dendritic Cells (pDCs) in human diseases. The chapters of the book discuss the origin and discovery, heterogeneity, development, and transcriptional regulation of pDCs. It also discusses the role of pDCs in human diseases, including cancers, metabolic disorders, and autoimmune/inflammatory diseases, and opportunities for pDC‐targeting therapies in these diseases. It also highlights the current understanding of pDC involvement in autoimmunity and alloreactivity and opportunities for pDC‐targeting therapies in the disorders. Lastly, it reviews the experimental methodologies and animal models that are used to explore the functions of pDCs.

Natural Products and Human Diseases: Pharmacology, Molecular Targets, and Therapeutic Benefits

Posted By: AvaxGenius
Natural Products and Human Diseases: Pharmacology, Molecular Targets, and Therapeutic Benefits

Natural Products and Human Diseases: Pharmacology, Molecular Targets, and Therapeutic Benefits by Amirhossein Sahebkar
English | EPUB | 2021 | 545 Pages | ISBN : 3030732339 | 34 MB

Natural products have a long history of use as folk medicines in several systems of traditional medicine. Extensive evidence from modern pharmacological studies has confirmed traditional applications, and unveiled the vast potential of naturally occurring compounds, particularly plant-derived phytochemicals, in the management of chronic human diseases. The past decade has witnessed a surge of findings from randomized controlled trials testifying the safety and efficacy of natural products as adjuncts or alternatives to standard-of-care medications for several illnesses. Biomolecular studies have unveiled hundreds of cellular and molecular targets for phytochemicals including key transcription factors, receptors, enzymes, hormones, neurotransmitters, cytokines, lipids, and non-coding RNAs.

Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases (Repost)

Posted By: AvaxGenius
Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases (Repost)

Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases By Jun Sun
English | EPUB | 2018 | 391 Pages | ISBN : 1493975331 | 2.3 MB

Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes.