"Melatonin: Molecular Biology, Clinical and Pharmaceutical Approaches" ed. by Cristina Manuela Drăgoi, Alina Crenguţa Nicolae

This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered.

Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.

Contents
1. Melatonin, the Integrative Molecule within the Human Architecture
2. How Can Molecular Pharmacology Help Understand the Multiple Actions of Melatonin: 20 Years of Research and Trends
3. An Overview of Melatonin as an Antioxidant Molecule: A Biochemical Approach
4. Melatonin and Its Indisputable Effects on the Health State
5. Melatonin and Exercise: Their Effects on Malondialdehyde and Lipid Peroxidation
6. Melatonin in Childhood Epilepsy and in Child Neurology
7. Measurement of Plasma Tryptophan Metabolites: Clinical and Experimental Application for Depression and Stress States Assessment
8. Salivary Melatonin at Night: Responding to the Night Lighting and Cow’s Milk Consumption at Breakfast in Japanese Junior High and University Students
9. Melatonin Modified Release Formulations Designed for Sleep Disorders


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