This book synthesizes the key concepts of immunosuppression and immunomodulation. A comprehensive understanding of these processes is necessary to develop vaccines and therapeutic interventions for diseases.

This book provides a comprehensive overview of phagocytosis and related cells in the immune response. It presents the basics of phagocytosis as well as discusses management and therapeutic strategies for infections.

This book covers all aspects of PET-CT including newer applications involving infection and inflammation and basic information on PET-CT new tracers. It explains the approach, protocols and miscellaneous applications about various infections and inflammation that helps in its early and better diagnosis in multiorgan and multisystem involvements in routine clinical practice.

For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status.

This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.

This book provides a comprehensive overview of how to use MRI for the imaging of lung disease. Special emphasis is placed on routine applications and the clinical impact of MRI in each setting. In addition, current technological developments are reviewed and information presented on dedicated applications of MRI in preclinical and translational research, clinical trials, and specialized institutions.

Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies.

This volume discusses how fatty acids are associated with various diseases and health conditions, such as cardiovascular disease, cancer, inflammation, autoimmune diseases, and metabolic disorders. This book covers biosynthesis and processing of fatty acids, which address human health and environmental concerns.

This book covers all aspects of PET-CT including newer applications involving infection and inflammation and basic information on PET-CT new tracers. It explains the approach, protocols and miscellaneous applications about various infections and inflammation that helps in its early and better diagnosis in multiorgan and multisystem involvements in routine clinical practice.

The present work corresponds to a compilation of independent contributions in the fields of endocrinology, immunity, cancer, neurobiology, and myology. Revision of current advances as well as novel findings in the form of original articles are presented in a balanced fashion. The book has been divided into three sections in line with the main subject: Molecular pathology of immune, inflammatory, and hemostatic disorders; Molecular pathology of endocrine and muscular disorders; and Molecular pathology of cancer: determinants and potential therapies. In the first section, contributing authors take the reader through the molecular pathology of immune responses, inflammation, and hemostasis, by collating an update on systemic autoimmune diseases, the therapeutic potential of statins in hemostasis, the effects of adrenergic stimulation on coagulation, the emerging field of physical burnout due to the mobility restrictions in response to the 2020 SARS-CoV-2 pandemic imposed worldwide, and the success of community-oriented muscular kinesic rehabilitation. The second section presents engaging results from a survey of iodine intake through the diet of pregnant females, an appraisal of the neuroprotective effect of dexmedetomidine, novel evidence on muscle physiopathology, describing the upregulation of CCL5/RANTES during cholestatic liver disease, the fibrotic response emerging in response to cholic and deoxycholic acids, and the altering effects of bile acids in autophagy and mitogenesis.

This book provides a systemic review of the development, function, and role of plasmacytoid Dendritic Cells (pDCs) in human diseases. The chapters of the book discuss the origin and discovery, heterogeneity, development, and transcriptional regulation of pDCs. It also discusses the role of pDCs in human diseases, including cancers, metabolic disorders, and autoimmune/inflammatory diseases, and opportunities for pDC‐targeting therapies in these diseases. It also highlights the current understanding of pDC involvement in autoimmunity and alloreactivity and opportunities for pDC‐targeting therapies in the disorders. Lastly, it reviews the experimental methodologies and animal models that are used to explore the functions of pDCs.

This edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the “hygiene hypothesis” by considering the human need for exposure to microorganisms from an evolutionary point of view.

This book covers all aspects of PET-CT including newer applications involving infection and inflammation and basic information on PET-CT new tracers. It explains the approach, protocols and miscellaneous applications about various infections and inflammation that helps in its early and better diagnosis in multiorgan and multisystem involvements in routine clinical practice.