Apoptosis and Other forms of Cell Death in the Regulation of Inflammation in Health and Disease

It has long been known that the host responses to apoptosis, especially those that govern inflammation and immunity, lie at the heart of many normal physiological processes in multiple organ systems. That such responses are likely to play key roles in the pathophysiology of many disease states has become increasingly clear. The capacity of apoptosis to influence tissue microenvironments and produce systemic effects, in addition to the relevance of other cell death processes including necroptosis, pyroptosis and ferroptosis, has many implications for regulating inflammatory mechanisms.