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A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.
More than seven years after the world has become a frozen wasteland, the remnants of humanity inhabit a gigantic, perpetually-moving train that circles the globe as class warfare, social injustice and the politics of survival play out.