Quantitative Methods for Precision Medicine: Pharmacogenomics in Action
Quantitative Methods for Precision Medicine: Pharmacogenomics in Action
English | 2023 | ISBN: 148221945X | 307 Pages | PDF (True) | 48 MB
English | 2023 | ISBN: 148221945X | 307 Pages | PDF (True) | 48 MB
Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response.