Organ System Crosstalk in Critical Illness
Organ System Crosstalk in Critical Illness: From Basic Pathophysiology to Clinical Management
English | 2025 | ISBN: 3032010233 | 491 Pages | PDF EPUB (True) | 30 MB
English | 2025 | ISBN: 3032010233 | 491 Pages | PDF EPUB (True) | 30 MB
Homeostasis and health of multicellular organisms with multiple organs depends on inter-organ communication. Tissue injury in one organ disturbs this homeostasis and can lead to disease in multiple organs, or multi-organ failure. Many routes of inter-organ crosstalk during homeostasis are relatively well known, but inter-organ crosstalk in disease still lacks understanding. Particularly, how tissue injury in one organ can drive injury at remote sites and trigger multi-organ failure with high mortality is poorly understood. Mechanistically, inter-organ crosstalk after tissue injury could involve soluble mediators and their target receptors, cellular mediators, in particular immune cells, as well as newly identified neuro-immune connections.