Statistical Methods in Genetic Epidemiology by Duncan C. Thomas
Statistical Methods in Genetic Epidemiology by Duncan C. Thomas
English | Jan. 29, 2004 | ISBN: 019515939X | 458 Pages | PDF | 25 MB
English | Jan. 29, 2004 | ISBN: 019515939X | 458 Pages | PDF | 25 MB
This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process.