Chromatographic Methods in Clinical Chemistry and Toxicology

This book aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts, which focus almost exclusively on clinical relevance and applications. Chromatography has a vast array of clinical applications, and though the chromatographic methods were first introduced decades ago, new applications of this technology are being used to explore previously inaccessible frontiers in clinical diagnostics and toxicological testing. An up-to-date book devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text, useful to students, laboratory technicians, and researchers.Content: Chapter 1 Quality Assurance, Quality Control and Method Validation in Chromatographic Applications (pages 1–14): Michele L. Merves and Bruce A. GoldbergerChapter 2 Liquid Chromatographic?Mass Spectrometric Measurement of Anabolic Steroids (pages 15–32): Don H. Catlin, Yu?Chen Chang, Borislav Starcevic and Caroline K. HattonChapter 3 High?Performance Liquid Chromatography in the Analysis of Active Ingredients in Herbal Nutritional Supplements (pages 33–55): Amitava DasguptaChapter 4 Measurement of Plasma L?DOPA and L?Tyrosine by High?Performance Liquid Chromatography as a Tumor Marker in Melanoma (pages 56–66): Thierry Le Bricon, Sabine Letellier, Konstantin Stoitchkov and Jean?Pierre GarnierChapter 5 Hypersensitive Measurement of Proteins by Capillary Isoelectric Focusing and Liquid Chromatography?Mass Spectrometry (pages 67–86): Feng Zhou and Murray JohnstonChapter 6 Chromatographic Measurement of Transferrin Glycoforms for Detecting Alcohol Abuse and Congenital Disorders of Glycosylation (pages 87–100): Anders HelanderChapter 7 Chromatographic Measurements of Catecholamines and Metanephrines (pages 101–126): Eric C. Y. Chan and Paul C. L. HoChapter 8 Chromatographic Measurement of Volatile Organic Compounds (VOCs) (pages 127–138): Larry A. BroussardChapter 9 Chromatographic Techniques for Measuring Organophosphorus Pesticides (pages 139–169): H. Wollersen and F. MusshoffChapter 10 Chromatographic Analysis of Nerve Agents (pages 170–196): Jeri D. Ropero?MillerChapter 11 History and Pharmacology of ??Hydroxybutyric Acid (pages 197–216): Laureen MarinettiChapter 12 Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection for Element Speciation: Clinical and Toxicological Applications (pages 217–273): Katarzyna Wrobel, Kazimierz Wrobel and Joseph A. CarusoChapter 13 Applications of Gas Chromatography?Mass Spectrometry to the Determination of Toxic Metals (pages 274–285): Suresh K. Aggarwal, Robert L. Fitzgerald and David A. Herold