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    Design and Analysis of Clinical Trials : Concepts and Methodologies

    Posted By: hotspot
    Review
    “…a comprehensive introduction…highly recommended…” (Statistical Methods in Medical Research, Vol. 14, 2005)

    "…I will find this book a handy resource for future consulting with medical researchers." (Journal of the American Statistical Association, June 2005)

    "…the authors have done a commendable job of blending large amounts of statistical and regulatory information in a way that is easy to comprehend and directly applicable…" (Clinical Chemistry, April 2005)

    “…provides a comprehensive overview of the rather general area of clinical trials…an essential reference text.” (Journal of Applied Statistics, Vol.32, No.3, April 2005)

    "Numerous real-life examples and illustrations form clinical case studies are included…" (Zentralblatt Math, Vol.1050, 2005)

    "…certainly comprehensive…should be a standard reference for both clinical scientists and biostatisticians…" (Technometrics, February 2005)

    Book Description
    Praise for the First Edition of Design and Analysis of Clinical Trials
    "An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area."
    -Statistical Methods in Medicine
    A complete and balanced presentation now revised, updated, and expanded
    As the field of research possibilities expands, the need for a working understanding of how to carry out clinical trials only increases. New developments in the theory and practice of clinical research include a growing body of literature on the subject, new technologies and methodologies, and new guidelines from the International Conference on Harmonization (ICH).
    Design and Analysis of Clinical Trials, Second Edition provides both a comprehensive, unified presentation of principles and methodologies for various clinical trials, and a well-balanced summary of current regulatory requirements. This unique resource bridges the gap between clinical and statistical disciplines, covering both fields in a lucid and accessible manner. Thoroughly updated from its first edition, the Second Edition of Design and Analysis of Clinical Trials features new topics such as:
    * Clinical trials and regulations, especially those of the ICH
    * Clinical significance, reproducibility, and generalizability
    * Goals of clinical trials and target population
    * New study designs and trial types
    * Sample size determination on equivalence and noninferiority trials, as well as comparing variabilities
    Also, three entirely new chapters cover:
    * Designs for cancer clinical trials
    * Preparation and implementation of a clinical protocol
    * Data management of a clinical trial
    Written with the practitioner in mind, the presentation assumes only a minimal mathematical and statistical background for its reader. Instead, the writing emphasizes real-life examples and illustrations from clinical case studies, as well as numerous references-280 of them new to the Second Edition-to the literature. Design and Analysis of Clinical Trials, Second Edition will benefit academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students in these areas by serving as a useful, thorough reference source for clinical research.

    download:
    http://rapidshare.de/files/19307988/Design.rar.html