The Mizoroki-Heck Reaction

Exploring the importance of Richard F. Heck’s carbon couplingreaction, this book highlights the subject of the 2010 Nobel Prizein Chemistry for palladium-catalyzed cross couplings in organicsynthesis, and includes a foreword from Nobel Prize winner RichardF. Heck.
The Mizoroki-Heck reaction is a palladium-catalyzedcarbon–carbon bond forming process which is widely used inorganic and organometallic synthesis. It has seen increasing use inthe past decade as chemists look for strategies enabling thecontrolled construction of complex carbon skeletons. TheMizoroki-Heck Reaction is the first dedicated volume on thisimportant reaction, including topics on:
- mechanisms of the Mizoroki-Heck reaction
- intermolecular Mizoroki-Heck reactions
- focus on regioselectivity and product outcome in organicsynthesis
- waste-minimized Mizoroki-Heck reactions
- intramolecular Mizoroki-Heck reactions
- formation of heterocycles
- chelation-controlled Mizoroki-Heck reactions
- the Mizoroki-Heck reaction in domino processes
- oxidative heck-type reactions (Fujiwara-Moritanireactions)
- Mizoroki-Heck reactions with metals other than palladium
- ligand design for intermolecular asymmetric Mizoroki-Heckreactions
- intramolecular enantioselective Mizoroki-Heck reactions
- desymmetrizing Mizoroki-Heck reactions
- applications in combinatorial and solid phase syntheses, andthe development of modern solvent systems and reactiontechniques
- the asymmetric intramolecular Mizoroki-Heck reaction in naturalproduct total synthesis
Several chapters are devoted to asymmetric Heck reactions withparticular focus on the construction of otherwisedifficult-to-obtain sterically congested tertiary and quaternarycarbons. Industrial and academic applications are highlighted inthe final section. The Mizoroki-Heck Reaction will find aplace on the bookshelves of any organic or organometallicchemist.
“I am convinced that this book will rapidly become themost important reference text for research chemists in academia andindustry who seek orientation in the rapidly growing and –for the layman – confusing field described as the“’Mizoroki–Heck reaction’.”(Synthesis, March 2010)