Tuberculosis Vaccines
English | 2025 | ISBN: 3031945395 | 795 Pages | PDF EPUB (True) | 21 MB
English | 2025 | ISBN: 3031945395 | 795 Pages | PDF EPUB (True) | 21 MB
Tuberculosis (TB) is the leading cause of death by an infectious agent worldwide. The Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against TB and the most widely used vaccine in history. Since 1921, billions of people have been vaccinated with BCG, resulting in a remarkable decline in infant mortality. However, although BCG's efficacy to prevent TB meningitis and disseminated disease in children is well established, its efficacy to prevent infection, disease or reactivation in adolescents and adults is variable. Therefore, novel TB vaccines are urgently needed. Recent clinical trials have shown promising results, offering hope for the introduction of a new generation of vaccines to replace or boost BCG.