Metal Ions and Neurodegenerative Disorders by Paolo Zatta
Metal Ions and Neurodegenerative Disorders by Paolo Zatta
English | Jan 2004 | ISBN: 9812383980 | 538 Pages | PDF | 30 MB
English | Jan 2004 | ISBN: 9812383980 | 538 Pages | PDF | 30 MB
Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events.