Microwave Assisted Organic Synthesis

The first reports on the application of microwaves in organic synthesis date back to 1986, but it was not until the recent introduction of specifically designed and constructed equipment, which countered the safety and reproducibility concerns, that synthetic application of microwaves has become established as a laboratory technique. Microwave assisted synthesis is now being adopted in many industrial and academic laboratories to take advantage of the novel chemistry that can be carried out using a variety of organic reaction types.This book demonstrates the underlying principles of microwave dielectric heating and, by reference to a range of organic reaction types, it's effective use in synthetic organic chemistry. To illustrate the impact microwave assisted organic synthesis can have on chemical research, case studies drawn mainly from the pharmaceutical industry are presented. Content: Chapter 1 Theoretical Aspects of Microwave Dielectric Heating (pages 1–22): D. Michael P. MingosChapter 2 Microwave?Acceleratedmetal Catalysis: Organic Transformations at Warp Speed (pages 23–43): Kristofer Olofsson and Mats LarhedChapter 3 Heterocyclic Chemistry Using Microwave?Assisted Approaches (pages 44–74): Thierry Besson and Christopher T. BrainChapter 4 Microwave?Assisted Reductions (pages 75–101): Timothy N. Danks and Gabriele WagnerChapter 5 Speed and Efficiency in the Production of Diverse Structures: Microwave?Assisted Multi?Component Reactions (pages 102–132): Jacob WestmanChapter 6 Integrating Microwave?Assisted Synthesis and Solid?Supported Reagents (pages 133–176): Ian R. Baxendale, Dr. Ai?Lan Lee and Prof. Steven V. LeyChapter 7 Microwave?Assisted Solid?Phase Synthesis (pages 177–221): Alexander Stadler and C. Oliver KappeChapter 8 Timesavings Associated with Microwave?Assisted Synthesis: A Quantitative Approach (pages 222–236): Christopher R. SarkoChapter 9 Scale?Up of Microwave?Assisted Organic Synthesis (pages 237–271): Brett A. Roberts and Christopher R. Strauss