Knowledge accumulation and industry evolution : the case of Pharma-Biotech

Written by internationally acclaimed experts in the economics of innovation, this volume examines how the biotechnology and pharmaceutical sector is affected by the dynamics of innovation, institutions, and public policy. It contributes both theoretically and empirically to the increasingly influential Schumpetarian framework in industrial economics, which places innovation at the centre of the analysis of competition. Both quantitative and qualitative studies are included, and this varied perspective adds to the richness of the volume's insights. The contributors explore different ideas regarding the historical evolution of technology in the sector, and how firms and industry structure have co-evolved with innovation dynamics. Important policy questions are considered regarding the future of innovation in this sector and its impact on the economy Introduction / Giovanni Dosi and Mariana Mazzucato -- pt. I. Innovation and industry evolution. Pharmaceutical innovation as a process of creative destruction / Frank R. Lichtenberg -- The evolution of pharmaceutical innovation / Paul Nightingale and Surya Mahdi -- Firm and regional determinants in innovation models : evidence from biotechnology and traditional chemicals / Myriam Mariani -- Innovation and industry evolution : a comment / Louis Galambos -- pt. II. Firm growth and market structure. Heterogeneity and firm growth in the pharmaceutical industry / Elena Cefis, Matteo Ciccarelli and Luigi Orsenigo -- Growth and diversification patterns of the worldwide pharmaceutical industry / Giulio Bottazzi, Fabio Pammolli and Angelo Secchi -- Entry, market structure, and innovation in a ''history-friendly'' model of the evolution of the pharmaceutical industry / Christian Garavaglia, Franco Malerba and Luigi Orsenigo -- The growth of pharmaceutical firms : a comment / Boyan Jovanovic -- pt. III. Policy implications. The effects of research tool patents and licensing on biomedical innovation / John P. Walsh, Ashish Arora and Wesley M. Cohen -- Upstream patents and public health : the case of genetic testing for breast cancer / Fabienne Orsi, Christine Sevilla and Benjamin Coriat -- Competition, regulation, and intellectual property management in genetically modified foods : evidence from survey data / Pierre Regibeau and Katharine Rockett -- Governance, policy, and industry strategies : pharmaceuticals and agro-biotechnology / Joyce Tait, Joanna Chataway, Catherine Lyall, and David Wield -- The dynamics of knowledge accumulation, regulation, and appropriability in the pharma-biotech sector : policy issues / Luigi Orsenigo, Giovanni Dosi and Mariana Mazzucato