The Stem Cell Microenvironment and its Role in Regenerative Medicine and Cancer Pathogenesis
The Stem Cell Microenvironment and its Role in Regenerative Medicine and Cancer Pathogenesis by Cristian Pablo Pennisi
English | PDF | 2017 | 144 Pages | ISBN : 8793379935 | 17.4 MB
How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation.
This book discusses some of the recent advances in stem cell research that may help understanding the properties of the niche that govern stem cell fate. Technical topics discussed include:
Stem cell biology
Cancer stem cells
Stem cell interactions with biomaterials
Engineering the stem cell microenvironment
Stem cells in tissue regeneration and repair
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