Drug Absorption Studies: In Situ, In Vitro and In Silico Models
Carsten Ehrhardt, Kwang-Jin Kim, "Drug Absorption Studies: In Situ, In Vitro and In Silico Models"
English | 2008 | ISBN: 0387749004 | PDF | pages: 706 | 6.0 mb
English | 2008 | ISBN: 0387749004 | PDF | pages: 706 | 6.0 mb
This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.