Oral Bioavailability Assessment
Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development
Wiley | English | 2017 | ISBN-10: 1118916697 | 448 pages | EPUB | 12.47 mb
Wiley | English | 2017 | ISBN-10: 1118916697 | 448 pages | EPUB | 12.47 mb
by Ayman F. El-Kattan (Author), Mike S. Lee (Series Editor)
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
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