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"Astrocyte: Physiology and Pathology" ed. by Maria Teresa Gentile and Luca Colucci D’Amato

Posted By: exLib
"Astrocyte: Physiology and Pathology" ed. by Maria Teresa Gentile and Luca Colucci D’Amato

"Astrocyte: Physiology and Pathology" ed. by Maria Teresa Gentile and Luca Colucci D’Amato
ITExLi | 2018 | ISBN: 9535138855 9789535138853 9535138863 9789535138860 | 226 pages | PDF | 14 MB

This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.

A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression.

Contents
1 Introductory Chapter: The Importance of Astrocytes in the Research of CNS Diseases
2 Signaling Pathways Regulating the Pathophysiological Responses of Astrocytes: A Focus on the IKK/NF-κB System
3 Evidence that Astroglia Influence Dendrite Morphogenesis and Synaptogenesis Independently in the Vertebrate Central Nervous System
4 NMDA Receptors in Astroglia: Chronology, Controversies, and Contradictions from a Complex Molecule
5 Astrocytes in Pathogenesis of ALS Disease and Potential Translation into Clinic
6 Astrocytes’ Role in Alzheimer’s Disease Neurodegeneration
7 Mitochondrial Function in Alzheimer’s Disease: Focus on Astrocytes
8 The Role of Astrocytes in Tumor Growth and Progression
9 Astrocytes in Aceruloplasminemia
10 Astrocyte Pathophysiology in Liver Disease

1st true PDF with TOC BookMarkLinks