"Leukemia: From Biology to Clinic" ed. by Margarita Guenova, Gueorgui Balatzenko

This book does not have the ambition to present comprehensively the problems of leukemias, but it is an attempt to acquaint the audience of specialists involved in clinical management and experimental research with some modern advances and concepts in the three main directions: biology, clinical presentation and treatment.

Medical professionals and researchers in the field of leukemias are faced with the need to continuously update their knowledge in a wide range of areas, ranging from fundamental molecular processes and mechanisms to a thorough understanding of clinical features and modern approaches to achieve maximum therapeutic results.
The biological aspects of the origin, development and therapy resistance of leukemias are within the scope of the first section. Comprehensive and concise information on the clinical assessment and treatment of leukemia patients is provided, as well as on some specific interdisciplinary clinical scenarios such as leukemic retinopathy, in the second section. Finally, challenges, current standards and recent advances in the therapy of acute leukemias comprise the third section of the book.

Contents
1. Genetic Polymorphisms of Xenobiotics-Metabolizing Enzymes Contributing to Leukemia
2. The Role of BAALC Gene in the Transformation of Myeloid Progenitor Cells to Acute Myeloid Leukemia
3. Roads of Drug Resistance in Acute Myeloid Leukemia – Is It a Dead End?
4. Chronic Myeloid Leukemia: Biology, Diagnosis, and Management
5. Clinical and Imaging Features of Leukemic Retinopathy
6. Management of Newly Diagnosed Acute Myeloid Leukemia in Older Adults
7. Allogeneic Transplantation of Hematopoietic Stem Cells (HSCs) for Acute Leukemia in Children – Review of Literature and Experience of Single Center in Russia
8. CRISPR-Cas9-based Strategies for Acute Lymphoblastic Leukemia Therapy


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