"Neuroblastoma" ed. by Hiroyuki Shimada

In this book, the world distinguished investigators report clinical and biological characteristics of this disease.

Tumors of neuroblastoma group are heterogenous and their molecular/genomic properties are closely related to the prognosis of patients: some children enjoy an excellent clinical course after biopsy/surgery alone, and others suffer from a fatal outcome even after an intensive treatment.
Recent progress has also started disclosing critical significance of cross-talking between neuroblastoma cells and their microenvironment in predicting clinical behaviors of individual cases.

Contents
Preface
Section 1 Neuroblastoma, Clinical
1 Clinical Presentation of Neuroblastoma
2 A Novel Diagnostic Tool for Therapy Stratification of Neuroblastoma: Preoperative Analysis of Tumor Biology Using Circulating Tumor-Released DNA in Serum
Section 2 Neuroblastoma, Biology -1
3 Close Neighbours on Chromosome 2 the ALK and MYCN Genes. Implications for Targeted Therapeutics in Neuroblastoma
4 Neurotrophin and Neurotrophin Receptor Involvement in Human Neuroblastoma
5 Connexin36 is a Negative Regulator of Differentiation in Human Neuroblastoma
6 Pathways of Intrinsic Apoptosis in Neuroblastoma: Targets for Therapeutics and New Drug Development
7 Analysis of Apoptotic and Autophagic Pathways in Neuroblastoma by Treatment with Copper Compounds
Section 3 Neuroblastoma, Biology - 2
8 Bone Marrow Infiltration in Neuroblastoma: Characteristics of Infiltrating Cells and Role of the Microenvironment
9 Neuroblastoma Integrins
Section 4 Neuroblastoma, Biology - 3
10 Novel Therapeutic Approaches for Neuroblastoma
11 miRNAs as Essential Mediators of the Actions of Retinoic Acid in Neuroblastoma Cells
12 Copper as a Target for Treatment of Neuroblastoma: Molecular and Cellular Mechanisms
13 Clinical Implications of Neuroblastoma Stem Cells