"Pulmonary Hypertension: From Bench Research to Clinical Challenges" ed. by Roxana Sulica and Ioana Preston

This textbook combines pulmonary and cardiac physiology and pathophysiology with clinical aspects of the disease. The textbook addresses the following topics: structure and function of the normal pulmonary vasculature; disregulated cellular pathways seen in experimental and human pulmonary hypertension; clinical aspects of pulmonary hypertension in general; presentation of several specific forms of pulmonary hypertension, and management of pulmonary hypertension in special circumstances.

First two sections are reserved for the basic knowledge and the recent discoveries related to structure and cellular function of the pulmonary vasculature. The chapters also describe disregulated pathways known to be affected in pulmonary hypertension.
A special section deals with the effects of hypoxia on the pulmonary vasculature and the myocardium.
Other three sections introduce the methods of evaluating pulmonary hypertension to the reader.
The chapters present several forms of pulmonary hypertension which are particularly challenging in clinical practice (such as pulmonary arterial hypertension associated with systemic sclerosis), and lastly, they address special considerations regarding management of pulmonary hypertension in certain clinical scenarios such as pulmonary hypertension in the critically ill.

Contents
Preface
Part 1 Pulmonary Vascular Function and Dysfunction
1 Pulmonary Hypertension: Endothelial Cell Function
2 Integrin-Mediated Endothelial Cell Adhesion and Activation of c-Src, EGFR and ErbB2 Are Required for Endothelial-Mesenchymal Transition
3 Interplay Between Serotonin Transporter Signaling and Voltage-Gated Potassium Channel (Kv) 1.5 Expression
4 Deregulation of BMP Signaling in the Pathogenesis of Pulmonary Hypertension
5 ω3 and ω6 CYP450 Eicosanoid Derivatives: Key Lipid Mediators in the Regulation of Pulmonary Hypertension
Part 2 Hypoxia and Its Effectson Pulmonary Vasculature and Heart
6 Hypoxic Pulmonary Arterial Hypertension in the Chicken Model
7 Inadequate Myocardial Oxygen Supply/Demand in Experimental Pulmonary Hypertension
Part 3 Clinical Evaluation and Diagnostic Approaches for Pulmonary Hypertension
8 Assessment of Structural and Functional Pulmonary Vascular Disease in Patients with PAH
9 Dyspnea in Pulmonary Arterial Hypertension
10 Echocardiography in Pulmonary Hypertension
Part 4 Several Clinical Forms of Pulmonary Hypertension
11 Pulmonary Hypertension in Systemic Sclerosis
12 Clinical Syndromes and Associations with Persistent Pulmonary Hypertension of the Newborn
13 Sarcoidosis Associated Pulmonary Hypertension
14 Pulmonary Hypertension in Patients with Chronic Kidney Disease
Part 5 Special Considerations in Evaluation and Management of Pulmonary Hypertension
15 Perioperative Management of Pulmonary Hypertension
16 Pregnancy and Pulmonary Arterial Hypertension
17 Pulmonary Hypertension in the Critically III