"Ubiquitin Proteasome System: Current Insights into Mechanism Cellular Regulation and Disease" ed. by Matthew Summers

The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's.


Contents
1.Ubiquitin Signaling in Regulation of the Start of the Cell Cycle
2.Processes that Regulate the Ubiquitination of Chromatin and Chromatin-Associated Proteins
3.E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting
4.The Role of Lysine 63-Linked Ubiquitylation in Health and Disease
5.Regulation of Selective Proteolysis in Cancer
6.Ubiquitin Carboxyl-Terminal Hydrolase L1 in Parkinson’s Disease
7.New Insights into the Mechanisms Underlying NEDD8 Structural and Functional Specificities
8.ADP-Ribosylation of the Ubiquitin C-Terminus by Dtx3L/Parp9
9.Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10
10.Zinc-Binding B-Box Domains with RING Folds Serve Critical Roles in the Protein Ubiquitination Pathways in Plants and Animals