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    Handbook of Single-Molecule Biophysics

    Posted By: AvaxGenius
    Handbook of Single-Molecule Biophysics

    Handbook of Single-Molecule Biophysics by Peter Hinterdorfer
    English | PDF | 2009 | 634 Pages | ISBN : 0387764968 | 23.2 MB

    The last decade has seen the development of a number of novel biophysical methods that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at this fundamental level of sensitivity has given rise to an improved understanding of the underlying molecular mechanisms.
    Through the removal of ensemble averaging, distributions and fluctuations of molecular properties can be characterized, transient intermediates identified, and catalytic mechanisms elucidated. By applying forces on biomolecules while monitoring their activity, important information can be obtained on how proteins couple function to structure. The Handbook of Single-Molecule Biophysics provides an introduction to these techniques and presents an extensive discussion of the new biological insights obtained from them. Coverage includes:

    Experimental techniques to monitor and manipulate individual biomolecules
    The use of single-molecule techniques in super-resolution and functional imaging
    Single-molecule studies of physical properties of biomolecules
    Single-molecule enzymology and biochemistry
    Single molecules in the membrane
    Single-molecule techniques in living cells
    Integration of single-molecule biophysics and nanoscience
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