The theory of blood circulation is the oldest and most advanced branch of biomechanics, with roots extending back to Huangti and Aristotle, and with contributions from Galileo, Santori, Descartes, Borelli, Harvey, Euler, Hales, Poiseuille, Helmholtz, and many others. It represents a major part of humanity's concept of itself. This book presents selected topics of this great body of ideas from a historical perspective, binding important experiments together with mathematical threads. The objectives and scope of this book remain the same as in the first edition: to present a treatment of circulatory biomechanics from the stand­ points of engineering, physiology, and medical science, and to develop the subject through a sequence of problems and examples. The name is changed from Biodynamics: Circulation to Biomechanics: Circulation to unify the book with its sister volumes, Biomechanics: Mechanical Properties of Living Tissues, and Biomechanics: Motion, Flow, Stress, and Growth. The major changes made in the new edition are the following: When the first edition went to press in 1984, the question of residual stress in the heart was raised for the first time, and the lung was the only organ analyzed on the basis of solid morphologic data and constitutive equations. The detailed analysis of blood flow in the lung had been done, but the physiological validation experiments had not yet been completed.

This book provides an interdisciplinary and comprehensible introduction to bioeconomy. It thus provides basic knowledge for understanding a transformation process that will shape the 21st century and requires the integration of many disciplines and industries that have had little to do with each other up to now. We are talking about the gradual and necessary transition from the age of fossil fuels, which began around 200 years ago, to a global economy based on renewable raw materials (and renewable energies). The success of this transition is key to coping with the challenge of climate change.

MTDSC provides a step-change increase in the power of calorimetry to characterize virtually all polymer systems including curing systems, blends and semicrystalline polymers. It enables hidden transitions to be revealed, miscibility to be accurately assessed, and phases and interfaces in complex blends to be quantified. It also enables crystallinity in complex systems to be measured and provides new insights into melting behaviour. All of this is achieved by a simple modification of conventional DSC.

“The human body is a machine whose movements are directed by the soul,” wrote René Descartes in the early seventeenth century. The intr- sic mechanisms of this machine gradually became clear through the hard work of Renaissance scientists. Leonardo da Vinci is one such scientist from this period of enlightenment. In pursuit of knowledge, Leonardo dissected the bodies of more than 30 men and women. He sawed the bones lengthwise, to see their internal structure; he sawed the skull, cut through the vertebrae, and showed the spinal cord. In the process, he took extensive notes and made carefully detailed sketches. His drawings d- ferentiated muscles that run across several joints from those muscles that act on a single joint. “Nature has made all the muscles appertaining to the motion of the toes attached to the bone of the leg and not to that of the thigh,” wrote Leonardo in 1504 next to one of his sketches of the lower extremity, “because when the knee joint is flexed, if attached to the bone of the thigh, these muscles would be bound under the knee joint and would not be able to serve the toes. The same occurs in the hand owing to the flexion of the elbow. ” Another Renaissance scholar who made fundamental contributions to the physiology of movement is Giovanni Alfonso Borelli. Born in 1604 in Naples, Borelli was a well-respected mathematician.

This book focuses on the current status of our understanding of RNA, a key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA, noncoding RNAs, modified nucleosides, and RNA enzymes. The different chapters detail methods to investigate RNA structure and function, the chemistry of modified RNAs, and the latest advances in our understanding of the vast array of biological processes in which RNA is involved.

The annual Computational Neuroscience Meeting (CNS) began in 1990 as a small workshop called Analysis and Modeling of Neural Systems. The goal of the workshop was to explore the boundary between neuroscience and computation. Riding on the success of several seminal papers, physicists had made "Neural Networks" fashionable, and soon the quantitative methods used in these abstract model networks started permeating the methods and ideas of experimental neuroscientists. Although experimental neurophysiological approaches provided many advances, it became increasingly evident that mathematical and computational techniques would be required to achieve a comprehensive and quantitative understanding of neural system function. “Computational Neuroscience” emerged to complement experimental neurophysiology. The Encyclopedia of Computational Neuroscience, published in conjunction with the Organization for Computational Neuroscience, will be an extensive reference work consultable by both researchers and graduate level students. It will be a dynamic, living reference, updatable and containing linkouts and multimedia content whenever relevant.

Natural products are a marvel of evolution. Plants are chemical factories and have produced a vast number of highly diverse and interesting natural substances with their extraordinary properties, which we humans have been using for centuries to relieve and cure diseases. At the latest since the discovery of penicillin, natural substances have become an important source of medicines, but we know only very few of the presumably many millions that are still waiting to be discovered. Important antibiotics, immunosuppressants, anticancer agents, hormones, and antiviral agents are among the natural products. But do natural products still matter in the age of biotechnology and genetic engineering? Yes, more than ever, because medicinal chemists draw creative inspiration for their syntheses from nature to develop the next blockbuster in medicine.

Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences.

The book introduces readers to the latest developments in biotechnological methods used for improving the cultivation of silkworms. The text focuses on implementing biotechnological approaches, ranging from basic to advanced techniques, on enhancing silk production, increasing abiotic stress resilience, improving disease tolerance, and developing resistance in silkworm crops. With the current climate crisis and growing demand for high-quality silk, biotechnological applications have become essential in addressing the urgent need to increase silk production. The field of sericulture has made significant breakthroughs, such as identifying DNA markers, linkage association, genome-wide association studies, generating mutants, and introducing transgenic silkworms. Developing silkworms with improved cocoon yield and disease resistance is crucial to boost silk production.

This book concerns two subthemes, 'temperature sensing' and 'temperature-responding systems', addressing the questions of how temperature is sensed and how temperature is related to biological functions, respectively. Temperature affects various physiological functions and is one of the most important factors in homeostasis. The book seeks to integrate our understanding of temperature-dependent biological phenomena with the development of techniques that detect and regulate local temperatures in cells and organs with high resolution and precision.

This book highlights the science underlying honey, which is central to an understanding of conventional medicine or ingredients of food used mostly in all societies and it is attracting increasing interest among food scientists and professionals worldwide. Honey, wax, propolis and royal jelly also have significant roles in various nutraceutical and pharmaceutical products and this book provides collective information and practical approaches regarding all characteristic features of honey and its applications as functional food and medicines. Not only does this book explain the comprehensive knowledge of honey and its medicinal properties based on current researched evidence, it also explores the contribution of honey in the food science and medicine industry as a significant part of nutraceuticals and functional food research. Written by leading scientists in the field, the book will be a valuable resource for students and researchers in the fields of food chemistry, nutritional science, taste physiology, and neuroscience, as well as for professionals in the food industry.

This book describes the basic concepts and recent advances in new discoveries and technologies related to microbial omics and their role in environmental research and human health. The term "omics" refers to a blend of high-throughput analysis and traditional methods including genomics, transcriptomics, proteomics, lipidomics and metabolomics for a variety of applications in the field of life sciences, biomedical sciences, environmental sciences, and related industries. The book aims to fill the existing gap in terms of a comprehensive approach that incorporates recent advances in this dynamic field and provides an answer to why this field requires an interdisciplinary research approach.

oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar­ macological targets in the treatment of a variety of disorders, such as epi­ lepsy, hypertension, and pain. Voltage-gated calcium channels have there­ fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl­ edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac­ tivity, the book delves into a provocative overview of the history of the cal­ cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat­ ing, permeation, modulation and interactions with members of the exo- totic machinery—contributed by both established leaders and rising stars in the field.

The objective of the book is to show the complementarity and integration of food and non-food value chains for the development of a sustainable bioeconomy. One current challenge facing industry and the economy is to meet the needs of a growing world population while preserving the environment. The use of fossil energy resources for several decades has generated a decrease in reserves of these resources, together with a phenomenon of global warming due to the release of greenhouse gases into the atmosphere. More and more industrial sectors, including the chemical industry, are replacing fossil carbon with renewable carbon. The bioeconomy consists in using renewable biological resources to produce food, materials, and energy. A bioeconomy based on the green chemistry and biotechnologies is developing worldwide, as a lever for reducing the ecological footprint of human activities. The book is articulated around six parts, each dedicated to a keystone of the interface betweengreen chemistry and Agro-Food Industry.