"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods" ed. by Sahra Kırmusaoğlu

To prevent bacterial adherence, invasion and infection, antimicrobials such as antibiotics are being used and vastly researched nowdays. The goal of this book is to provide information on all these topics.


Several factors such as natural selection, mutations in genes, the presence of efflux pumps, impermeability of the cell wall, structural changes in enzymes and receptors, biofilm formation, and quorum sensing cause microorganisms to develop resistance against antimicrobials. Isolates that synthesize extended spectrum-β-lactamases (ESBL), induced β-lactamases (IBL), carbapenamases, metallo-β-lactamases (MBLs), and New Delhi metallo-β-lactamases (NDM) have emerged. Determining virulence factors such as biofilms and the level of antimicrobial activities of antimicrobial agents alone and in combination with appropriate doses against microorganisms is very important for the diagnosis, inhibition, and prevention of microbial infection.

Contents
1. Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance.
2. Antimicrobial Resistance.
3. Alternative Approaches to Combat Medicinally Important Biofilm-Forming Pathogens.
4. Origin and Control Strategies of Biofilms in the Cultural Heritage.
5. Antimicrobial Agents: Antibacterial Agents, Anti-biofilm Agents, Antibacterial Natural Compounds, and Antibacterial Chemicals.
6. The Methods for Detection of Biofilm and Screening Antibiofilm Activity of Agents.
7. Streptomyces as a Source of Antimicrobials: Novel Approaches to Activate Cryptic Secondary Metabolite Pathways.