"Chagas Disease: From Cellular and Molecular Aspects of Trypanosoma cruzi: Host Interactions to the Clinical Intervention"

This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions.

Even 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite’s success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines.

Contents
1. Chagas Disease – A Multidisciplinary Old Public Health Problem
2. New Therapeutics for Chagas Disease: Charting a Course to Drug Approval
3. The Saga of Selenium Treatment Investigation in Chagas Disease Cardiopathy: Translational Research in a Neglected Tropical Disease in Brazil
4. Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning
5. Digestive Disorders in Chagas Disease: Megaesophagus and Chagasic Megacolon
6. How Do Mouse Strains and Inoculation Routes Influence the Course of Experimental Trypanosoma cruzi Infection?
7. Modulation of Host Cell Apoptosis by Trypanosoma cruzi: Repercussions in the Development of Chronic Chagasic Cardiomyopathy
8. Evaluation of Molecular Variability of Isolates of Trypanosoma cruzi in the State of Rio de Janeiro-Brazil


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