"Medicinal Chemistry and Drug Design" ed. by Deniz Ekinci

This book contains an overview focusing on the research area of enzyme inhibitors, molecular aspects of drug metabolism, organic synthesis, prodrug synthesis, in silico studies and chemical compounds used in relevant approaches. The book deals with basic issues and some of the recent developments in medicinal chemistry and drug design. Particular emphasis is devoted to both theoretical and experimental aspect of modern drug design. The primary target audience for the book includes students, researchers, biologists, chemists, chemical engineers and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in chemistry, protein biochemistry, enzymology, molecular biology and genetics many of which are active in biochemical and biomedical research.

The textbook will enhance the knowledge of scientists in the complexities of some medicinal approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of medicinal chemistry and drug design.

Contents
Preface
1 Kojic Acid Derivatives
2 Analysis of Protein Interaction Networks to Prioritize Drug Targets of Neglected-Diseases Pathogens
3 Recent Applications of Quantitative Structure-Activity r Relationships in Drug Design
4 Atherosclerosis and Antihyperlipidemic Agents
5 Inhibitors of Serine Proteinase - Application in Agriculture and Medicine
6 Pyrrolobenzodiazepines as Sequence Selective DNA Binding Agents
7 Regulation of ЕС-SOD in Hypoxic Adipocytes
8 Development of an Ultrasensitive CRP Latex Agglutination Reagent by Using Amino Acid Spacers
9 Pattern Recognition Receptors Based Immune Adjuvants: Their Role and Importance in Vaccine Design
10 Microarray Analysis in Drug Discovery and Biomarker Identification
11 Supraventricular Tachycardia Due to Dopamine Infused Through Epidural Catheter Accidentally (A Case Report and Review)
12 Effective Kinetic Methods and Tools in Investigating the Mechanism of Action of Specific Hydrolases
13 Aluminium - Non-Essential Activator of Pepsin: Kinetics and Thermodynamics
14 Peptides and Peptidomimetics in Medicinal Chemistry
15 Carbonic Anhydrase Inhibitors and Activators: Small Organic Molecules as Drugs and Prodrugs
16 Stochastic Simulation for Biochemical Reaction Networks in Infectious Disease
17 Alternative Perspectives of Enzyme Kinetic Modeling
18 Molecular Modeling and Simulation of Membrane Transport Proteins