"Post-Translational Modifications in Cellular Functions and Diseases" ed. by Shibo Ying

This book intends to provide the reader with an overview of the current state of the art in this research field, which focuses on the recent advances, new findings and perspectives in cellular functions, and their clinical significance in human diseases. This book will help researchers in this area.

Post-Translational Modifications (PTMs) may occur at any stage following the translation process in the lifecycle of specific proteins. PTMs regulate several cellular processes including protein stability, subcellular localization, and protein-protein interactions. In recent years, more and more target proteins of PTMs have been proved to be related to epigenetic regulation and cell fate. Some enzymes that catalyze PTMs have also been found to be involved in human diseases.

Contents
1. Regulation of MAPK ERK1/2 Signaling by Phosphorylation: Implications in Physiological and Pathological Contexts
2. Post-Translational Regulation of the Activity of ERK/MAPK and PI3K/AKT Signaling Pathways in Neuroblastoma Cancer
3. Epigenetic Control of Mesenchymal Stromal Cell Fate Decision
4. The Function of FEN1 is Regulated by Post-Translational Modification
5. p300/CBP Methylation is Involved in the Potential Carcinogenic Mechanism of Lung Cancer
6. The Role of Protein Arginine Methyltransferase 1 in Gastrointestinal Cancers


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