This updated work is an all-in-one book, encompassing the essential aspects of radiation physics, radiobiology, and clinical radiation oncology.

This thesis investigates estimation in innovative oncology trial designs, with emphasis on basket and master protocols. It links design choices to estimators and quantifies trade-offs between bias, variance, and interpretability. Chapter 2 develops an unbiased UMVUE and exact confidence intervals for response rates in stopped Simon's two-stage designs, showing that early stopping can save resources while modestly reducing precision. Chapter 3 studies the Restricted Mean Duration of Response (RMDoR) under right/interval censoring, clarifying the role of the truncation time τ, proposing practical estimators, and demonstrating that RMDoR ratios provide robust, comparable efficacy summaries. Chapter 4 benchmarks Bayesian information-borrowing estimators for cohort-specific response in single-stage basket trials, revealing context-dependent performance and sensitivity to prior specification. Chapter 5 extends the evaluation to two-stage basket designs (motivated by DRUP), introducing simulation-based tuning to select models and hyperparameters under mean and worst-case utilities; 4 methods was used on this research, EXNEX is generally stable, while Berry, Psioda, and Fujikawa can excel when carefully tuned. Overall, the work argues that estimation is integral to design, advocates prespecifying borrowing strategies and parameter grids, and highlights the need for clearer guidance on transparent prior/tuning choices in precision-oncology trials.

This atlas covers all aspects of retina, retinal pigment epithelium, and choroidal tumors, as well as other simulating lesions of intraocular tumors and paraneoplastic syndromes. Each chapter features numerous high-quality pictures based on multimodal imaging, including color fundus photography, fundus autofluorescence, optical coherence tomography, ultrasonography, ultra-widefield imaging, and fundus angiography.

This book provides the reader with a focused review of multimodality imaging strategies (radiology and molecular imaging) in staging and re-staging the major types of cancer (i.e. thyroid, breast, colon-rectum, lung, prostate, pancreas, liver, head and neck, and hematological cancer), including rare neoplasms.

This book elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin.

This updated work is an all-in-one book, encompassing the essential aspects of radiation physics, radiobiology, and clinical radiation oncology.