A pianist of legendary fame and stature, Vladimir Horowitz was born in Kiev, Ukraine. His mother, herself a professional pianist, provided his first instruction at the piano and was the first to recognize his extraordinary talents; he studied further at the Kiev Conservatory. His first public appearance was a recital in Kiev on May 30, 1920, and in 1922 he gave a series of 15 concerts in Kharkov for which he was paid in food and clothing. Although Russia was still reeling from the revolution of 1917, Horowitz fashioned successful concert tours in major cities such as Moscow, Leningrad, and Kiev – marking the beginning of a performing career of unflagging and spectacular success.

Introduction to GNSS Geodesy is a concise reference for beginners and experts in GNSS-based satellite geodesy. It covers all of the important concepts in almost a third of the space of the other GNSS books. Th e book begins with a case study in Augmented Reality to set the stage for what is to come and then moves on to the key elements of GNSS geodesy that make accurate and precise geopositioning possible.

Anne-Sophie Mutter is widely regarded as one of the greatest violinists of modern times, combining technical virtuosity, beauty of tone, and exceptional charisma. She has nurtured the classical music scene through her own Anne-Sophie Mutter Foundation, which has commissioned new works and fostered the careers of younger violinists. Mutter was born in the German town of Rheinfelden, near the Swiss border, on June 29, 1963. She took up the piano at five, and the violin shortly after. By nine she was advancing rapidly and had begun lessons with Aïda Stucki. Mutter appeared in recital at the Lucerne Festival when she was 13 and was heard there by legendary conductor Herbert von Karajan.

This handbook provides an innovative, thorough overview of service management. It draws together an impressive, international group of leading scholars who offer a truly global perspective, exploring current literature and laying out guidance for future research. Beginning with defining service as a perspective on value creation, and service management as “a set of organizational competencies for enabling and realizing value creation through service,” it then moves on to follow the evolution of service research. From there, the book is structured into six main themes: perspectives on service management; service strategy; service leadership and transition; service design and innovation; service interaction; quality and operations; and service management and technology.

Although endometriosis and adenomyosis are often assessed under the same umbrella, the epidemiology, clinical manifestations and management strategies of endometriosis and adenomyosis occur differently during the life cycle of a woman. Endometriosis can be diagnosed at many points across the lifespan, including adolescence and the climacterium, as well as pregnancy. Being associated with potential adverse health effects, different clinical presentations requiring different therapeutic approaches render it imperative to tailor management strategies for each period of the lifespan: in utero and early life, puberty and adolescence, reproductive years, pregnancy, late reproductive age, and the menopause.

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g.

This volume addresses the latest state-of-the-art systems biology-oriented approaches that–driven by big data and bioinformatics–are utilized by Computational Systems Biology, an interdisciplinary field that bridges experimental tools with computational tools to tackle complex questions at the frontiers of knowledge in medicine and biotechnology.