"Serotonin and the CNS: New Developments in Pharmacology and Therapeutics" ed. by Berend Olivier

This volume illustrates the broadness of the involvement of serotonergic activity in many processes, focusing particularly on disorders of the brain, including depression, stress and fear, Alzheimer’s disease, aggression, sexual behavior, and neuro-immune disorders.

Serotonin is an ancient neurotransmitter system involved in various systems and functions in the body and plays an important role in health and disease. Chapters illustrate techniques and methods used to study the complex role of the serotonergic system in all kinds of processes, present new hypotheses for several brain disorders like sleep and depression, and use mathematical modeling as a tool to advance knowledge of the extremely complex brain and body processes.

Contents
1. Mathematical Models of Serotonin, Histamine, and Depression
2. Serotonin, Sleep and Depression: A Hypothesis
3. Roles of the Serotoninergic System in Coping with Traumatic Stress
4. Small Molecule Drugs for Treatment of Alzheimer’s Diseases Developed on the Basis of Mechanistic Understanding of the Serotonin Receptors 4 and 6
5. Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors
6. Experimental Serotonin Syndrome: Effects of GABA-ergic Medications and 5-HT2-Antagonists
7. Role of 5-HT in Cerebral Edema after Traumatic Brain Injury
8. Serotonin Pathway in Neuroimmune Network


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