This book reviews the interface of stem cell biology and biomaterials for regenerative medicine. It presents the applications of biomaterials to support stem cell growth and regeneration. The book discusses the stem cell interactions’ with nanofiber, gradient biomaterial, polymer- and ceramic biomaterials, integrating top-down and bottom-up approaches, adhesive properties of stem cells on materials, cell-laden hydrogels, micro-and nanospheres, de-cellularization techniques, and use of porous scaffolds. Further, this book provides a basic introduction to the fabrication techniques for creating various biomaterials that can be used for stem cell differentiation.

Brain organoids are small stem cell-derived, self-organizing models of specific brain regions that offer researchers new ways to study the human brain. Since their scientific debut over ten years ago, brain organoids have been used to generate tractable new bioengineered tools for understanding functional interconnectivity of the human brain, dysfunction involved in many neurodegenerative diseases, and certain molecular mechanisms underlying cognition.

New fabrication techniques and biomaterials have advanced significantly as attention toward healthcare innovations in recent decades has increased. This book provides a comprehensive overview of the application of additive manufacturing for biomedical devices. The book focuses on the use of biomaterial for hard and soft tissue engineering. These materials can imitate the mechanical, structural, and biological characteristics of the parent tissue, repairing or replacing its functioning. It provides details on the use of various biomaterials for different biomedical applications. It highlights the present trends and potential of various techniques and materials for various applications. The chapters in this book written by eminent experts highlight recent developments in additive manufacturing for biological mimicking and surgical planning. It discusses latest advances in various 3D printing technologies in the fabrication of biomedical devices for orthopaedic and cardiovascular applications, along with rising trends in designing and creating tissue replacement substitute simulants. This book can serve as a fundamental textbook for research in additive manufacturing, fabrication of implants or scaffolds and medical device development, biomaterials, tissue engineering, and biomedical engineering. This book can be a valuable resource for mechanical and biomedical engineers, academicians, healthcare researchers, and professionals interested in tissue engineering.

This book is the second edition of the one originally published in 2016, which focused on state-of-the-art microfluidic research in medical and biological applications. Similar to the first edition, beginners in the field —undergraduates, engineers, biologists, medical and pharmaceutical researchers—will easily learn to understand microfluidic-based medical and biological applications. Because a wide range of topics is summarized here, it also helps experts to learn more about fields outside their own specialties. In this second edition, significant revisions have been made to chapters covering technologies that have seen major advancements, such as acoustofluidics, protein crystallography, organ-on-a-chip systems, nanopore sensing, and paper-based microfluidics. In addition, the chapters on cancer diagnosis using exosomes and single-cell sequencing using droplet microfluidics, which are attracting attention as new technologies, have been newly added. Readers will be convinced that microfluidic devices have great potential for medical and biological applications.

This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies.

"Handbook on Biomaterials for Medical Applications: Fundamentals" is a critical monograph that merges advanced technological insights with practical applications in biomedical materials science. It navigates through the intricate blend of theoretical knowledge and real-world medical practices, highlighting the significant roles these materials play in enhancing therapeutic outcomes. Addressing the interdisciplinary nature of the field, the book incorporates perspectives from chemistry, biology, engineering, and clinical medicine. This comprehensive guide covers novel biomaterials, advanced drug delivery systems, innovative tissue engineering, and the emerging field of theranostics, providing a holistic view of how these elements drive medical advancements. This book can be a valuable reference for scholars, researchers, and healthcare practitioners. Its text is richly illustrated with diagrams and tables, facilitating both the understanding and application of complex concepts. With an educational narrative accessible to both experts and beginners, the monograph encourages a passion for innovation and a deep understanding of the transformative potential of multifunctional biomedical materials. It invites readers to explore the confluence of materials science and therapeutic innovation, setting the stage for future breakthroughs in medical science and therapy. It can also be prescribed as a textbook for various graduate and undergraduate courses like tissue engineering and regenerative medicine, nanomedicine, biomedical engineering and biomaterials science and engineering.

This book reviews the interface of stem cell biology and biomaterials for regenerative medicine. It presents the applications of biomaterials to support stem cell growth and regeneration. The book discusses the stem cell interactions’ with nanofiber, gradient biomaterial, polymer- and ceramic biomaterials, integrating top-down and bottom-up approaches, adhesive properties of stem cells on materials, cell-laden hydrogels, micro-and nanospheres, de-cellularization techniques, and use of porous scaffolds. Further, this book provides a basic introduction to the fabrication techniques for creating various biomaterials that can be used for stem cell differentiation.

Soft tissue simulants, essential for automotive and ballistic testing, medical, and surgical training, have traditionally relied on cadavers and animal tissues. However, their biomechanical properties change with time due to dehydration after death and the biomechanics of the animal models cannot be translated and compared with the human tissues. This book compiles various synthetic tissues used in these applications, addressing their characterization and industry-wide applications. While older simulants lack biofidelity, recent advancements in biofidelic soft tissue simulants offer promising alternatives, yet technology transfer remains limited. This book fills the gap by exploring each simulant's characteristics and current trends, facilitating their adoption in clinical and academic settings. These synthetic tissues have the potential to replace live tissues in surgical training, streamlining biosafety approvals. They also benefit academic researchers by reducing costs and time in biomechanical testing. Anticipated to be the first of its kind, this comprehensive reference book will showcase recent advancements in soft tissue simulant development, serving as a cornerstone text in tissue engineering & biomedical engineering, medical simulation, biomechanics, and related fields.

Regenerative medicine is an emerging and integral part of interventional pain management and meets definitions of interventional pain management and interventional techniques. Interventional techniques are defined as minimally invasive procedures including, percutaneous precision needle placement, with placement of drugs in targeted areas or ablation of targeted nerves; and some surgical techniques such as laser or endoscopic diskectomy, intrathecal infusion pumps, and spinal cord stimulators, for the diagnosis and management of chronic, persistent, or intractable pain. On the same token, interventional pain management is defined as the discipline of medicine devoted to the diagnosis and treatment of pain related disorders principally with the application of interventional techniques in managing subacute, chronic, persistent, and intractable pain, independently or in conjunction with other modalities of treatment.

This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular diseases, neurological and ocular diseases, pediatrics, and the role of cancer stem cell-derived exosomal microRNA payload in lung cancer. The chapter reviews emerging stem cell therapy and tissue engineering approaches in neurodegenerative diseases. The book further examines the applications of stem cells in various fields of dentistry, and for the regeneration of oral and non-oral tissues. The chapters also explore the application of 3D bioprinting in conjunction with bone marrow mesenchymal stem cells for the treatment of bone defects and state-of-the-art technology for bone and cartilage regeneration using mesenchymal stem cells. The book presents stem cell-based therapy against renal, pancreatic, and kidney diseases and examines the advantages of a novel hepatic stem for cirrhotic liver repair and regeneration. Lastly, the book provides methodological and procedural advancements in stem cell-based therapy, including the applications of single-cell sequencing in stem cell research. This handbook is a major one-stop reference for researchers working in regenerative medicine, cellular pharmacology, stem cell research in general, and those involved in specific areas of adult stem cells as well as embryonic and induced pluripotent stem cells.

This book presents the latest knowledge, trends, and advances in cell transplantation and innovations in developing microspheres, 3D biomaterial constructs to enhance transfer, and cell survival to specific regions of the brain. Neurodegenerative diseases and brain injury are increasing. Medications currently only temporarily reduce some of the symptoms but do not cure or delay progression of the disease.

The book examines recent developments in regenerative medicine and the use of musculoskeletal ultrasound. Musculoskeletal regeneration has become a prominent research topic, no doubt due to the sociological and economic pressures imposed by the current ageing population. The ever expanding role of regenerative medicine and the identification as well as characterization of stem cells have introduced a major paradigm shift in the field of musculoskeletal and sports medicine as well as orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue.

This book reviews the interface of stem cell biology and biomaterials for regenerative medicine. It presents the applications of biomaterials to support stem cell growth and regeneration. The book discusses the stem cell interactions’ with nanofiber, gradient biomaterial, polymer- and ceramic biomaterials, integrating top-down and bottom-up approaches, adhesive properties of stem cells on materials, cell-laden hydrogels, micro-and nanospheres, de-cellularization techniques, and use of porous scaffolds. Further, this book provides a basic introduction to the fabrication techniques for creating various biomaterials that can be used for stem cell differentiation.

This book reports on the latest research and developments in Biomedical Engineering, with a special emphasis on topics of interest and findings achieved in Latin America. This first volume of a 4-volume set covers advances in modeling and simulation of biological and biomedical systems, mechanical characterization, and biological evaluation of biomaterials for medical applications, including tissues regeneration. It also covers some related special topics, such as advanced methodologies for agricultural and food production and public health management. Throughout the book, a special emphasis is given to low-cost technologies and to their development for and applications in clinical settings. Based on the IX Latin American Conference on Biomedical Engineering (CLAIB 2022) and the XXVIII Brazilian Congress on Biomedical Engineering (CBEB 2022), held jointly, and virtually on October 24-28, 2022, from Florianópolis, Brazil, this book provides researchers and professionals in the biomedical engineering field with extensive information on new technologies and current challenges for their clinical applications.