A leukemia patient attempts to end a 20-year feud with her sister to get her bone marrow.

Ten years after their divorce, Jane and Jake Adler unite for their son's college graduation and unexpectedly end up sleeping together. But Jake is married, and Jane is embarking on a new romance with her architect. Now, she has to sort out her life—just when she thought she had it all figured out.

Violet Weston (Meryl Streep) has cancer and a propensity for pills and alcohol. She's a difficult woman to deal with and her husband has finally had enough. Violet's family gathers including middle daughter Ivy, youngest daughter Karen (with her new fiancé), eldest daughter Barbara (with her separated husband and teenage daughter), and her sister Mattie Fae (with her husband and son in tow). A family tragedy causes tensions to run high and secrets to come out. The Weston women will be forced to examine themselves and their lives whether they want to or not. Welcome to Osage County, Oklahoma in the sweltering heat of August.